PECULIARITIES OF THE BEHAVIOR OF SUCCINYL DICHLORIDE IN FRIEDEL-CRAFTS REACTION WITH THIOPHENES

The reactions of thiophene, 2-methyl-, and 2-bromothiophene with succinyl dichloride in the presence of AlCl 3 , TiCl 4 , and SnCl 4 have been studied. The effect of the  acylation conditions, the relative amounts and nature of the Lewis acid on the ratio and yields of the 1,4-di(2-thienyl)-1,4-diones and 4-oxo-4-(2-thienyl)butyric acids formed have been demonstrated. Under the reaction conditions, the formation of 4,4-di(2-thienyl)but-3-enoic acids (the main products in many cases) and also 4,4-di(2-thienyl)-butyrolactones was demonstrated. How to Cite Smirnov, V. I.; Afanas'ev, A. V.; Belen'kii, L. I. Chem. Heterocycl. Compd. 2011 , 46 , 1199. [ Khim. Geterotsikl. Soedin. 2010 , 1485.] For this article in the English edition see DOI 10.1007/s10593-011-0653-z