Moderate Vitamin D Deficiency and Inflammation Related Markers in Overweight/Obese Schoolchildren

Objective: Obesity has been associated with vitamin D deficiency and increased oxidative stress, which can lead to the dysregulation of adipokines and inflammation. The aim of the present work was to examine the association of vitamin D status [25(OH)D] on inflammatory related markers in overweight/obese children. Subjects/Methods: A total of 137 Spanish schoolchildren between 9 and 12 years of age (31.4 % with overweight/obesity) were studied. Being overweight was defined as BMI ≥ 85th percentile and obesity as BMI ≥ 97th percentile using the reference tables of Hernandez. Serum 25(OH)D concentrations were measured by chemiluminescent assay. Plasma tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) were measured by immunoenzyme assay. Serum adiponectin was determined using an ELISA kit. Serum high-sensitivity C-reactive protein (hs-PCR) was tested by immunonephelometry. Results: IL-6 concentrations were higher in the overweight/obese children with deficient serum 25(OH)D (< 20 ng/mL) than in those in...