Whipple's disease with neurological manifestations: case report.

ABSTRACT - Whipple´s disease (WD) is an uncommon multisystem condition caused by the bacillus Tropheryma whipplei. Centralnervous system involvement is a classical feature of the disease observed in 20 to 40% of the patients.We report the case of a 62yeards old man with WD that developed neurological manifestations during its course,and discuss the most usual signs and symp-toms focusing on recent diagnostic criteria and novel treatment regimens.KEY WORDS:Whipple´s disease, inflammatory bowel disease, dementia, polyneuropathy.Doenca de Whipple com manifestacoes neurologicas: relato de casoRESUMO - A doenca de Whipple (DW) e disturbio multissistemico raro causado pelo bacilo Tropheryma whipplei. O envolvimentodo sistema nervoso central e um aspecto classico da doenca, sendo observado em 20 a 40% dos pacientes. Relatamos o caso dehomem de 62 anos com DW que desenvolveu manifestacoes neurologicas durante sua evolucao,com o objetivo de discutir os sinaise sintomas mais comuns e destacar os criterios diagnosticos e propostas terapeuticas mais recentes.PALAVRAS-CHAVE: doenca de Whipple, doenca inflamatoria intestinal, demencia, polineuropatia