Two receptor binding regions of human FSH show sense-antisense similarity to the human FSH receptor

The sequences of two receptor binding regions of the β-subunit of the human follicle-stimulating hormone (hFSH-β) were compared with the DNA-derived antisense peptide sequence of the hFSH receptor. A striking sense-antisense similarity was established between these receptor binding regions and the hFSH receptor. Based on this sense-antisense similarity four putative hormone binding regions on the N-terminal extracellular region of the hFSH receptor are identified.