Anti-GAD antibodies, a rare cause of limbic encephalitis: a case report

Limbic encephalitis refers to an inflammatory process involving the hippocampal regions, amygdala and less frequently frontobasal and insular regions. Symptoms include changes in behavior and mood such as irritability and depression, sleep disturbances, seizures, and short-term memory deficits. Two forms do exist: paraneoplastic and nonparaneoplastic. We describe a patient with a nonparaneoplastic form of limbic encephalitis, associated with anti-GAD antibodies, with good response to plasma exchange. Case report