Multidrug Resistance Bacteria in Different Clinical Samples in National Medical College and Teaching Hospital Birgunj, Nepal

A cross-sectional study was conducted in National Medical College and Teaching Hospital, Birgunj to study of multidrug resistant (MDR) bacteria in different clinical samples. Altogether 281 clinical samples were investigated in this study where 227 were urine samples and 54 were pus samples during the working period from March to September, 2010. A total of 76 (33.48%) urine samples and 37 (68.52%) pus samples were found to be positive. Analysis of the sample showed that UTI (Urinary tract infection) was more common in female as compared to male. It was found that 19(65%) E. coli were multidrug resistant out of 49 isolates isolated from 281 samples (including Urine, Pus), 9 (54.50%) Staphylococcus aureus were multidrug resistant out of 34 isolates. Similarly 5 (94.44%) Klebsiella pneumonia out of 11 isolates, 2 (58.33%) Pseudomonas aeruginosa out of 7 isolates, 1(50%) Enterococcus faecalis out of 2 isolates were multidrug resistant. Antimicrobial drug resistance is a major problem in Nepal. This study shows that a good percentage of people were infested by multi-drug resistant bacterial agents. The information provided in the study may be useful in improving control programmes directed against infectious disease in the Terai region of Nepal.