Systematic review of influence on pharmacokinetics of voriconazole on CYP2C19 genetic polymorphisms

Objective To evaluate the influence of CYP2C19 genetic polymorphisms on voriconazole pharmacokinetics.Methods Cochrane library,PubMed,Embase,CNKI databases were searched by computer for investigating the influence of CYP2C19 genetic polymorphisms on voriconazole pharmacokinetics.The researches were reported before February 2010.The Meta analysis was performed by RevMan 5.0 software.Results Ten retrospective studies,with 9 literatures in English and 1 literature in Chinese.The results of Meta analysis showed: There was no statistically significant among three genotypes of Cmax;Differences among the AUC and T1/ 2 is very obvious,PM genotype group were greater than the HEM genotype,and the HEM genotype group were significantly higher than EM genotype group.EM genotype group was significantly greater than PM genotype group in CL/F,PM genotype group was significantly longer than EM group in Tmax,PM genotype group was significantly greater than the EM group in MRT.Conclusion Voriconazole exposure is not only influenced by CYP2C19 genetic polymorphism,but by other reasons,and large sample prospective studies are needed.