LIPID PEROXIDATION MEASURED AS SERUM MALONDIALDEHYDE AND VITAMIN-C AS OXIDATIVE-ANTIOXIDATIVE BIOMARKERS IN TYPE II DIABETIC PATIENTS

Background: Oxidative stress (OS) has been implicated in the initiation, progression and pathology of type 2 diabetes mellitus (DM) and its associated complications. Methods: Serum samples were screened for lipid peroxidation marker, malondialdehyde (MDA), Vitamin C (Vit-C), and lipid parameters from 35 type 2 diabetic patients without complications and 30 non-diabetic healthy controls. Results: There were significant differences in all biochemical parameters in diabetic group compared to control group with a significant elevation in all the parameters but Vit-C and high density lipoproteins (HDL) found to be decreased significantly (p<0.05). Pearson’s correlation analysis revealed that MDA was found to be negatively correlated with Vit-C (r = 0.28, p<0.05). Conclusion: Type 2 DM is associated with lipid abnormalities and OS causing increased lipid peroxidation and depleted antioxidant levels. As these changes might lead to diabetic complications, our findings suggest the supplementation of antioxidants as a therapeutic measure to type 2 DM patients.