CONTENTS OF PLASMA HOMOCYSTEINE AND CENTRAL HEMODYNAMICS IN PATIENTS WITH VITAMIN B12 DEFICIENCY ANEMIA

The analysis of the relationship of central hemodynamic parameters and homocysteine levels with varying degrees of severity and duration of vitamin B12 defi ciency anemia. Consider the following characteristics: stroke volume, inute volume of blood, systolic index, left ventricular work index, specifi c peripheral vascular resistance. Revealed that the majority of patients with vitamin B 12 defi ciency anemia occurs hyperhomocysteinemia (p < 0,01), the intensity of which directly veil of severity of anemia, as well as the duration of the disease (p < 0,05). Both in the fi xed compensatory hyperkinetic type of central hemodynamic that as the disease progresses transformed into hypokinetic. According to the non-parametric correlation analysis studied central hemodynamic were signifi cantly associated with the level of hyperhomocysteinemia (r = 0,6; p < 0,05).