Endovascular In Situ Fenestration Technique of Aortic Arch Pathology: A Systematic Review and Meta Analysis.

ABSTRACT Objective: The aim of this study was to evaluate the safety, applicability and outcomes of the endovascular in situ fenestration (ISF) technique for patients with aortic arch pathologies by performing a systematic review. Methods: We conducted a systematic search using the PubMed, Embase, and Cochrane databases to identify English language articles between January 2004 and March 2019 on the management of aortic arch pathologies using an in situ fenestration technique. Two independent observers selected studies for inclusion in the study, assessed the methodological quality of the included studies, and extracted the data. The studies included all investigated the clinical outcomes and postprocedural complications of using ISF techniques. Results: Seven studies reported on a total of 117 aortic arch pathologies patients. Including fifty-two dissection patients, forty-seven aneurysm patients, eighteen intramural hematomas and penetrating ulcers patients. Needle fenestration and laser fenestration were performed in sixty-two and forty-five patients respectively, and the rest ten patients received radiofrequency fenestration. The follow-up period ranged from 1 to 55 months. The pooled technical success rates were 94% (95% confidence interval [CI]: 79-98%). The stroke rate was 6% (95% CI: 3-13%). The 30-day MAE was 11% (95% CI: 6-18%). Conclusion: The results of the study showed that using the in-situ fenestration technique for treating patients with aortic arch pathologies produced encouraging mid-outcomes. Long-term outcomes remain undefined.