Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation.

Pu-Hyeon Cha,Yong-Hee Cho,Sang Kyu Lee,Jaeheon Lee,Woo-Jeong Jeong,Byoung San Moon,Ji Hye Yun,Jee Sun Yang,Sooho Choi,Juyong Yoon,Hyun Yi Kim,Mi Yeon Kim,Saluja Kaduwal,Weon Tae Lee,Do Sik Min,Hoguen Kim,Gyoonhee Han,Kang-Yell Choi

Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation.

2016

Pu-Hyeon Cha
Yong-Hee Cho
Sang Kyu Lee
Jaeheon Lee
Woo-Jeong Jeong
Byoung San Moon
Ji Hye Yun
Jee Sun Yang
Sooho Choi
Juyong Yoon
Hyun Yi Kim
Mi Yeon Kim
Saluja Kaduwal
Weon Tae Lee
Do Sik Min
Hoguen Kim
Gyoonhee Han
Kang-Yell Choi

A small-molecule compound binds to the RGS domain of axin, promotes the degradation of β-catenin and Ras through the GSK3β-mediated destruction complex, and reduces the growth of KRAS and APC mutant colorectal cancer cell lines.

Keywords:

Beta-catenin
Molecular biology
Small molecule binding
RGS Proteins
Wnt signaling pathway
Catenin
Biology
Proto-Oncogene Proteins p21(ras)
Axin Protein
Anti-apoptotic Ras signalling cascade

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