A comparative study of Bayesian optimal interval (BOIN) design with interval 3 + 3 (i3 + 3) design for phase I oncology dose-finding trials

Yanhong Zhou,Ruobing Li,Fangrong Yan,J. Jack Lee,Ying Yuan

A comparative study of Bayesian optimal interval (BOIN) design with interval 3 + 3 (i3 + 3) design for phase I oncology dose-finding trials

2020

Yanhong Zhou
Ruobing Li
Fangrong Yan
J. Jack Lee
Ying Yuan

Bayesian optimal interval (BOIN) design is a model-assisted phase I dose-finding design to find the maximum tolerated dose. The hallmark of the BOIN design is its concise decision rule—making the d...

Keywords:

Bayesian probability
dose finding
Medical physics
Computer science

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