A Pilot Study Comparing Uric Acid and Biomarkers of Renal Injury and Inflammation in Pediatric Sickle Cell Disease at Vaso-Occlusive Crisis and Steady State
2019
Hyperuricemia hastens the decline of renal function in chronic kidney disease and activates the pro-inflammatory Nlrp3 inflammasome. Studies from the 1970s posited that high rates of hyperuricemia seen in sickle cell anemia (SCA) patients were due to high nucleotide production resulting from a chronic ischemia activated bone marrow. As such, serum uric acid (UA) levels may vary between states of vaso-occlusion.
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