New carboxylic acids and derivatives for the treatment and prevention of diabetes and dyslipaemias

The present invention relates to a compound of the formula: and its derivatives, solvates and pharmaceutically acceptable stereoisomers and their mixtures in all proportions. It also relates to pharmaceutical compositions comprising them and their use in particular for the treatment and prevention of diabetes and dyslipidemies.R1 and the group R4 borne by the carbon alpha to CR1R2 represent nothing and a double bond connects carbon atoms CR1R2 CR3R4 located alpha; or one of the radicals R1 and R2 form with one of radicals R3 and R4 aliphatic saturated or unsaturated hydrocarbon chain, optionally substituted; one of R5 and R6 represents W, and the other represents Z which is selected from an aliphatic hydrocarbon radical, saturated or unsaturated; a carbocyclic radical or heterocyclic saturated, unsaturated and / or aromatic, optionally substituted; an -alk-Cy in which alk represents an alkylene chain and Cy represents a heterocyclic or carbocyclic saturated, unsaturated and / or aromatic, optionally substituted; W is -XL-CO2R7; -XL-Tet wherein X and L are as defined below and Tet represents optionally substituted tetrazole; whereinL represents a saturated aliphatic or unsaturated hydrocarbon chain optionally substituted and / or optionally interrupted by arylene, optionally substituted; X is O; NR8 where R8 is H; a saturated aliphatic hydrocarbon group; -CO-R 'or -SO2-R' wherein R 'takes one of the meanings given below for R 7 with the exception of H; or R8 represents an optionally substituted aromatic carbocyclic group; or X is S (O) m where m is selected from 0, 1 and 2; R7 is H; a saturated or unsaturated aliphatic hydrocarbon group; a saturated carbocyclic group, unsaturated and / or aromatic, optionally substituted; a saturated heterocyclic group, unsaturated and / or optionally substituted aromatic, and derivatives thereof, pharmaceutically acceptable solvates and stereoisomers and mixtures thereof in all proportions.