Total synthesis of 2-(2-hydroxyalkyl)-piperidine alkaloids (−)-halosaline and (−)-8-epi-halosaline via iterative asymmetric allylation/RCM strategy

Abstract Total synthesis of 2-(2-hydroxyalkyl)-piperidine alkaloids, (−)-halosaline and (−)-8- epi -halosaline is reported from n -butyraldehyde using iterative asymmetric allylation, nucleophilic substitution with an azide and ring-closing metathesis as the key reactions.