Peptidases and neuropeptide processing

Part 1 Molecular approaches for the study of intracellular processing enzymes: molecular strategies for identifying processing enzymes, N.G. Seidah "in situ" hybridization techniques to map processing enzymes, M.K.-H. Schafer and R. Day analysis of ontogeny of processing enzyme gene expression and regulation, M. Zheng and J.E. Pintar use of vaccinia virus vectors to study neuropeptide processing, J.K. VanSlyke et al overexpression of neuropeptide precursors and processing enzymes, I. Lindberg and Y. Zhou use of antisense RNA to block peptide-processing enzyme expression, R.E. Mains. Part 2 Immunological and biochemical approaches to the study of peptide-processing pathways: combination of high-performance liquid chromatography and radioimmunoassay for characterization of peptide-processing pathways, A.I. Smith and R.A. Lew development and use of two-site immunometric assays for examining peptide-processing pathways, S.R. Crosby methods for identification of neuropeptide-processing pathways, P. Cohen et al immunological and related techniques for studying neurohypophyseal peptide-processing pathways, H. Gainer et al approaches to assessing ontogeny of processing enzymes, R.G. Allen and J. Stack measurement, distribution and subcellular localization of peptide-amidating activity, R.A. Lew and A.I. Smith methods for studying carboxypeptidase, L.D. Fricker characterization of endothelin-converting enzymes, T.J. Opgenorth et al "in vivo" approaches for studying peptide processing, A. Shulkes. Part 3 Identification and characterization of extracellular processing enzymes in the central nervous system: identification and characterization of central nervous system peptidase activities, J.R. McDermont and A.M. Gibson strategies for characterizing, cloning and expressing soluble endopeptidases, M.J. Glucksman and J.L. Roberts proteolytic processing and amyloid protein precursor of Alzheimer's disease, D.H. Small et al strategies for measurement of angiotensin and bradykinin peptides and their metabolites in central nervous system and other tissues, D.J. Campbell et al distribution and roles of endopeptidase 24.11, A.J. Turner and K. Barnes identification and distribution of endopeptidase 24.16 in the central nervous system, F. Checler et al autoradiographic techniques to map angiotensin-converting enzyme in brain and other tissues, S.Y. Chai and F.O. Mendelsohn.