Effects of redox interference on the pancreatic mitochondria and the abnormal blood glucose

Reactive oxygen species (ROS) has been implicated as a contributor to both the onset and the progression of diabetes, however how does redox state affect diabetes has not been fully understood. Here we study the role of redox interference on pancreatic mitochondria and the progression of diabetes. We applied streptozotocin (STZ) to establish diabetes mellitus (DM) model in rats, applied FeSO4 to produce oxidative stress (OS) and Ganoderma lucidum polysaccharides as antioxidant intervention (AO). Our results showed that in OS and DM group, oxidative stress caused the imbalance of redox state, resulting in higher lipid peroxidation level and lower antioxidant level, while AO treatment group reduced blood glucose by repairing the redox balance. The insulin level has the order of Normal Control (NC)

Keywords:

• Endocrinology
• Diabetes mellitus
• Antioxidant
• Internal medicine
• Oxidative stress
• Mitochondrion
• Streptozotocin
• Lipid peroxidation
• Chemistry
• Insulin
• Reactive oxygen species

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