Pulmonary Infiltrates with Eosinophilia Associated with Tetracycline

Two cases of diffuse skin rash and pulmonary infiltrates with eosinophilia (PIE) associated with administration of a tetracycline drug alone and subsiding after discontinuance of the drug are presented. The clinical course and appearance of the chest roentgenograms suggest that the dermal and pulmonary changes represented hypersensitivity reactions to tetracycline.