Hepatoprotective Activity of Methanolic Extract of Oldenlandia herbacea Against D - Galactosamine Induced Rats

Summary: The present study is to evaluate the hepatoprotective activity of methanolic extract of Oldenlandia herbacea against D - Galactosamine/ Lipopolysacharide (D - GalN) induced rats. Hepatoprotective activity was performed by using the toxicant D-GalN (200 mg/kg) in Wistar rats. Methanolic extract of the whole plant of O. herbacea was administered orally at doses of 100 and 200 mg/kg/day for 8 days. Silymarin (100 mg/kg) was used as standard drug. Levels of various biochemical parameters in serum the histopathology of liver were assessed to study the hepatoprotective effect of the extract.  The extract showed significant reduction in the D-GalN induced liver damage and symptoms of liver injury by restoration of the deviated levels of various biochemical parameters of liver which were observed in toxic control group. Histopathology of the liver sections confirmed that the extract prevented hepatic damage induced by D-GalN. The methanolic extract of O. herbacea showed significant hepatoprotective activity. Industrial relevance: The herbal drugs continue to serve as an important source of conventional therapies for diverse disease conditions and reactions. This is a preliminary study and this will support us to isolate the biological active phyto-constituents for treating liver disorders. This study will help in discovering a new or active phytochemicals and thus create a novel hepatoprotective moiety with less adverse effect for the betterment of the human society and more affordable and accessible to the users. Keywords: Oldenlandia herbacea ; D-galactosamine; Hepatoprotective activity; Silymarin.