High-sensitive Troponin I in acute cardiac conditions: Implications of baseline and sequential measurements for diagnosis of myocardial infarction

Abstract Background High-sensitive Troponin I (hsTnI) facilitates the early diagnosis of myocardial infarction (MI). However, since hsTnI has not been well characterized in non-ischemic cardiac conditions, the predictive value of hsTnI for MI remains unclear. Methods hsTnI (ADVIA Centaur, Siemens) on admission was analyzed in 929 patients with acute cardiac condition and invasive ascertainment of coronary status by catheterization. Results Hs-TnI upon presentation was higher in patients with STEMI (median 1.27ng/mL, IQR 0.13–14.5ng/mL) as compared to patients with Non-STEMI (0.66ng/mL, IQR 0.10–4.0ng/mL, p Conclusions HsTnI is a sensitive, albeit unspecific marker of MI. In patients with mildly elevated hsTnI and without evidence for STEMI, we suggest serial assessment of hsTnI and a 10-fold higher cutpoint of 0.40ng/mL before Non-STEMI is assumed.