[Prognostic significance of albumin/globulin ratio on postoperative survival of patients with hepatocellular carcinoma].

Objective To investigate the prognostic value of albumin/globulin ratio on postoperative survival outcomes in patients with hepatocellular carcinoma. Methods Data of 630 patients with HCC, who underwent surgical resection from February 2009 to July 2013, were retrospectively analyzed. Patients were divided into low-value group (A/G < 1.5, defined as L group) and high-value group (A/G≥1.5, defined as H group), and their distribution characteristics were observed with the normal A/G threshold value. Independent risk factors’ affecting survival and prognosis was analyzed with univariate and multivariate Cox’s regression model. Survival trend of all patients with low-value and high-value groups in A, B and C of Barcelona stage (BCLC stage) were analyzed using the Kaplan-Meier method. Results Multivariate analysis showed that preoperative A/G ratio (P = 0.007), alpha-fetoprotein (P 0.05). The long-term survival advantage existed in patients with Barcelona stage A (P 0.05). Conclusion Preoperative albumin/globulin ratio can predict postoperative prognosis and survival, and direct towards the treatment for early stage of HCC and thus representing as an indicator of high clinical value. Key words: Carcinoma, hepatocellular; Albumin/globulin ratio; Liver function; Inflammation; Survival prognosis