BINDING ABILITY OF IMPROMIDINE, A POTENT H2 HISTAMINE AGONIST AND ITS ANALOGUES

Abstract Potentiometric and spectroscopic (UV–VIS, EPR) methods were used to establish the co-ordination equilibria in Cu 2+ -impromidine solutions. Impromidine, a strong H 2 histamine agonist, was found to be an effective ligand co-ordinating to the Cu 2+ ion via two imidazole rings with the formation of a 15-membered macrochelate. CuL and CuL 2 are the major complexes formed, with a bis-complex dominating at physiological pH.