Atm Haploinsufficiency does not Affect Ionizing Radiation Mutagenesis in Solid Mouse Tissues

Abstract Connolly, L., Lasarev, M., Jordan, R., Schwartz, J. L. and Turker, M. S. Atm Haploinsufficiency does not Affect Ionizing Radiation Mutagenesis in Solid Mouse Tissues. Radiat. Res. 166, 39–46 (2006). Ataxia telangiectasia (AT) is a hereditary disease with autosomal recessive inheritance of ATM (ataxia telangiectasia mutation) alleles. AT is associated with severe sensitivity to ionizing radiation and a strong predisposition to develop cancer. A modest increase in cancer, particularly for the breast, has been shown for ATM carriers (i.e. heterozygotes), and a modest increase in radiation sensitivity has also been shown for those patients and their cells. However, the extent of these effects is unclear. Based on the well-established relationship between cancer and mutation, we used a mouse model for Atm haploinsufficiency to ask whether partial loss of Atm function could lead to an increased mutagenic response for solid tissues of mice exposed to radiation. The autosomal mouse Aprt gene was used as ...