Risk Factors for Chronic Graft Dysfunction in 918 Renal Transplants

(40% vs 25%), graft perfusion with Euro-Collins solution (37% vs 19%), DGF (40% vs 25%), and AR (44% vs 16%) (Table 1). The immunosuppressive regimen of azathioprine (Aza) prednisone (Pred) was associated with the highest (37%) incidence of CD and mycophenolate mofetil (MMF) CyA Pred with the lowest (13%) risk. In this series of renal transplants, CD emerged as the second cause of graft failure, with a rate of 30.6%, after death with a functioning graft (DWFG) with a 40.6% rate. We found a clear influence of AR on CD as a cause of graft loss: with 0, 1, or 1 AR episodes the graft loss due to CD was 22%, 43.5%, and 59%, respectively. The 1-year SCr significantly correlated with later development of CD (40% of CD with SCr 1.2 mg/dL vs 12% of CD with SCr 1.2 mg/dL). Graft survival rates at 1, 3, 5, 10, and 15 years were 98%, 86%, 68%, 36%, and 23% in the CD group, respectively, and 99%, 95%, 92%, 84%, and 74% in the group without CD, respectively. These differences in graft survival were statistically significant (P .000) (Fig 1). Patient survival rates at 1, 3, 5, 10, and 15 years were 99%, 96%, 90%, 70%, and 57% in the CD group, respectively, and 99%, 96%, 92%, 85%, and 75% in the group without CD, respectively. These differences in graft survival were also statistically significant (P .0016).