CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis

Fuqiang Wang,Wenxing Zhao,Yuehong Gao,Jiechao Zhou,Huifang Li,Guanyun Zhang,Dong Guo,Chengrong Xie,Jie Li,Zhenyu Yin,Jie Zhang

CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis

2019

Fuqiang Wang
Wenxing Zhao
Yuehong Gao
Jiechao Zhou
Huifang Li
Guanyun Zhang
Dong Guo
Chengrong Xie
Jie Li
Zhenyu Yin
Jie Zhang

Background CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear.

Keywords:

Hepatocellular carcinoma
Carcinogenesis
Tamoxifen
Biology
Cyclin-dependent kinase 5
Cancer research
Apoptosis
Cyclin-dependent kinase
Phosphorylation
Metastasis
Molecular biology
Cell growth
Cell migration
Gene knockdown
Cell culture

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