Short communication Derivative (1;18)(q10;q10) in essential thrombocythemia

This study reports the association of the chromosomal abnormality derivative (1;18)(q10;q10) with essential thrombocythemia (ET) occurring in a 75-year-old woman. Allele-specific polymerase chain reaction also revealed a V617F mutation in the Janus Kinase 2 gene (JAK2) in the platelet compartment in this patient. The der(1;18)(q10;q10) abnormality has previously been reported in two cases of myeloid disorders. The etiological implications for ETof this combination of chromo- somal abnormality and JAK2 mutation still remain elusive. This is a novel report of derivative