Compounds and methods for modulating receptors FX

A compound of formula p is 0 or 1; R1 and R2 are independently selected from the group consisting of hydrogen, -C1-C6-C6 -haloalquiloC1, -C1-C6 -haloalkoxy 1 -C 6, halo, -SR11 and -S-C1-C3 ; each R3 is independently selected from the group consisting of -C1-C6 alkyl, C1-C6 haloalkyl, -alcoxiC1-C6, C1-C6 -haloalkoxy and halo; R4 is selected from the group consisting of hydrogen, -C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 alkynyl, I -alkylcycloalkyl C4-C8, C1-C6 alkoxy and C1-C6 -haloalkoxy; R5 and R5a are independently selected from the group consisting of hydrogen and -C1-C3; R6 is selected from the group consisting of hydrogen, -C1-C6 alkyl, C1-C6 haloalkyl and halo; Ar1 is selected from the group consisting of indolyl, pyridinyl, thienyl, benzothienyl, indazolyl, benzothiazolyl, benzisoxazolyl, benzofuranyl and thiazolyl, each optionally substituted with one or two seleccionadosindependientemente groups from the group consisting of hydroxy, -C1-C6 , C3-C8 cycloalkyl, C4-O2 -alquilC1-alkyl-C1-C2, C1-C4 alkyl-S-C1-C2, -C1-C4-NR10R11, phenyl, -C1-C4-O-alkyl and C1-C4-NHC (O) R10; R7 is selected from the group consisting of -CH2COOR10, -COOR 10, -CONR11R11, -C (O) NHSO2-C1-C4 alkyl, -C (O) NHSO2R12, and oxadiazolone oxadiazoletiona; each R10 is independently selected from the group consisting of hydrogen, -C1-C4 alkyl and phenyl; each R11 is independently hydrogen or -C1-C6 alkyl; R12 is -C1-C6 alkyl or phenyl optionally substituted with C1-C3 alkyl, or a pharmaceutically acceptable salt thereof aceptabledel.