卵巢浆液性腺癌组织中MMP-2、MT1-MMP的表达变化及意义

Objective To observe the the expression of MMP-2 and MT1-MMP in ovarian serous adenocarcinoma tissue, and explore its mechanism. Method Immunohistochemical PV6000 method was used to detect the expression of MMP-2 and MT1-MMP in 30 benign serous adenomas, 30 borderline serous adenomas and 50 serous adenocarcinomas of ovary. Results The positive expression rates of MMP-2 and MT1-MMP in human ovarian serous adenocarcinomas and borderline serous adenomas were higher than that in human benign serous adenomas (P＜0.05). The positive expression rates of MMP-2 and MT1-MMP were significantly related to the metastasis, clinical stage and histological grade of human ovarian serous adenocarcinomas (P＜0.05). The positive expression rates of MMP-2 and MT1-MMP in patients who dead in 2 years were greatly higher than that beyard 2 years (P＜0.05). There was a positive correlationship between the expression of MT1-MMP and MMP-2 in serous adenocarcinomas of ovary (r(subscript s)=0.61, P＜0.01). Conclusion MMP-2 and MT1-MMP may play grate role in the origin, invasion and metastasis of ovarian serous adenocarcinomas, and be act as an important index to predict the biological behavior in carcinoma.