Efficient oxidative N-dealkylative addition of trialkylamines to dimethyl acetylenedicarboxylate using BrCCl3 as the terminal oxidant

Abstract Herein we present a continuous improvement of visible-light mediated N -dealkylative addition of tertiary amines to dimethyl acetylenedicarboxylates (DMAD) using alkyl halogenides as external oxidants together with base additives. This method is highlighted by excellent tolerance with various tertiary amines and good to excellent yields in short reaction time under mild conditions.