P277 - Clinical features of ulcerative colitis in pANCA-positive patients in Russian Federation

murine model. Moreover, Ussing Chamber analysis shows that the intestinal permeability is maintained similar to the one of untreated mice, and colon length results comparable to untreated animals. In addition, both the systemic and local analysis of cytokines shows an increase of the anti-inflammatory cytokine IL-10 and a reduction of inflammatory cytokines. Conclusions: These results show that SGLT-1 activation may restore the gut barrier function, usually lost during chronic colitis, and contrast with the inflammatory status. Activation of SGLT-1 by D-glucose, orally administered, may be suggested as a new pharmacological approach for the treatment of Crohn’s disease.