An acid-free Pictet–Spengler reaction using deep eutectic solvents (DES)

Abstract Deep eutectic solvents (such as the combination of either urea or glycerol with choline chloride) are effective solvents/organocatalysts for Pictet–Spengler condensations to form carbolines. The reaction conditions are quite mild and do not require additional Bronsted or Lewis acid catalyst. Given the inexpensive, non-toxic, and recyclable nature of the DES, these reaction conditions are simple and highly environmentally friendly.