Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue A 18F‐fluorodeoxyglucose positron emission tomography study

To investigate the pathophysiology of fatigue in MS, we assessed cerebral glucose metabolism (CMR-Glu) in 47 MS patients using PET and 18 F-fluorodeoxyglucose. Applying the Fatigue Seventy Scale (FSS), we first compared MS patients with severe fatigue (MS-FAT, n = 19, FSS > 4.9) and MS patients without fatigue (MS-NOF, n = 16, FSS