Curcumin loaded sericin nanoparticles: Assessment for biomedical application

Abstract The present study is aimed at formulating Genipin crossed curcumin loaded sericin NPs (Cur-SNPs) for the biomedical application in terms of anti-inflammatory and antioxidant potential. Cur-SNPs were prepared by employing modified desolvation method and crosslinking using genipin (Gn) and optimization for particle size, drug entrapment and loading. The optimized curcumin loaded sericin NPs (Opt-Cur-SNPs) exhibited particle size (263±3.5 nm), entrapment efficiency (85.7 ± 1.20%), drug loading (47.0 ± 1.23%) and zeta potential (-25.65 mV). The in-vitro drug release data revealed that 72.0 ± 2.3% and 83.1 ± 1.0% curcumin release over a span of 60 h in simulated gastric fluid and colonic pH. In-vivo antioxidant activity and anti-inflammatory activity showed significant results (p