No pathogen-specific sign or symptom predicts the etiology of monomicrobial nongonococcal urethritis in men.

Identifying pathogen-specific signs or symptoms of nongonococcal urethritis (NGU) could improve syndromic management accuracy. We evaluated NGU signs and symptoms in 220 men with single-pathogen infections (Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, or Ureaplasma urealyticum) or idiopathic urethritis. No individual sign or symptom accurately predicted the infectious etiology.