MRI contrast enhancement (CE): Analysis as survival prognostic factor in low grade gliomas (LGG).

e14031Background: LGG are heterogeneous diseases, and factors related to poor prognosis have not been completely determined. MRI CE at follow-up has been related with progression to high grade glioma (HGG), however its role at the time of diagnosis remains less understood. The aim of our study was to determine the prognostic value of CE at the time of diagnosis in patients with histologically proved LGG. Methods: A retrospective longitudinal study was designed. Data from clinical records of all patients with histological diagnosis of LGG from Jan 2006 to Apr 2016 were collected. Diagnostic MRI was re-evaluated to define tumor size, midline compromise (MLC) and CE. IDH1 status by IHC was also determined. Cases with histological evidence of HGG at any follow-up time were excluded. Results: Sixty-six patients (43 astrocytoma, 11 oligoastrocytoma and 12 oligodendroglioma [WHO 2007]) were included for analysis: 24 with CE (36.4%) and 42 without CE (63.6%). No significant differences in clinical and treatment-r...