Correspondence on 'Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial'.

Did the first randomised trial of faecal microbiotal transplantation in psoriatic arthritis have a negative outcome due to the paradoxical triggering of a reactive type arthritis disease flare? We read with great interest the report by Kragsnaes et al on faecal microbiota transplantation (FMT) in active psoriatic arthritis (PsA).1 The authors cited the example of reactive arthritis (ReA) as an exemplar of how dysregulation of the intestinal microbiome may contribute to the immunopathogenesis of human arthritis by disturbance of the gut–joint axis. We appreciate that limitations in word count may have constrained Kragsnaes et al on commenting further on gut dysbiosis in arthritis. PsA, ankylosing spondylitis (AS), the related inflammatory bowel disease (IBD)-associated arthropathies and ReA all fit within the umbrella term …