Comparison of the Blood Clearance Tests of 99mTc-Phytate and Indocyanine Green in Liver-Injured Rats with Carbon Tetrachloride.

The comparative study of the blood clearance tests of 99mTc-phytate (99mTc-P) and indocyanine green (ICG) was undertaken in liver-injured rats with carbon tetrachloride (CCl4) .The blood clearances of 99mTc-P and ICG in rats decreased with the increase in dose of CCl4 and with the time elapsed after CC14 administration, As compared with the blood clearance test of ICG, the blood clearance test of99mTc-P in rats was found to be more sensitive in detection of the hepatic dysfunction with mildly damaged stage, but to be relatively inaccurate in detection of the hepatic dysfunction with severely damaged stage induced by CCl4.