The Study for the Action of Cyclosporin A on Cerebral Ischemia-Reperfusion-Injury in Rats

Objective: To explore the protective action of Cyclosporin A on the cerebral ischemia-reperfusion-in jury in rats. Methods: 108 wistar rats were divided into 3 groups, which were sham operation group,saline control groups and cy-closporin A treatment group. The focal cerebral ischemia-reperfusion-injury model was made by suture occluded method. The behavior obstacles of rats were observed. The cerebral cell apoptosis was detected by flow cytometry. The cerebral slices were stained with TTC methods. The morphological changes in cerebra were observed with the electro-microphones. Results: Compared between the cyclosporin A group and the saline group in scheduled time,the score of behavior obstacles in the cyclosporin A group was better than the saline group(P0. 05); both the infarct volume and the percentage of cerebral cell apoptosis were markedly decreased than the saline group(P0. 05) ;the result of electro microphones showed that the morphological changes were less serious in cyclosporin A group compared with the saline group; the sham operation group have no obvious abnormal change in each observational item. Conclusions: The result suggested that the immune factors may play important role in cerebral ischemic reperfusion injury of rats. Cyclosporin A could have protective effect on cerebral ischemic reperfusion injury in rats.