Potentiometric Sensing of Lamotrigine Based on Molecularly Imprinted Polymers

In the present work a novel potentiometric sensor, based on a noncovalent imprinted polymer, was developed for determination of Lamotrigine (LTG). At optimized conditions the electrode exhibited a Nernstian response (30.8 � 1.0 mV decade � 1 ) in a concentration range of 1 � 10 � 6 to 1 � 10 � 3 M with a detection limit of 8 � 10 � 7 mol L � 1 . The potential response of the electrode was constant in the pH range of 1.0–5.0. The electrode demonstrated a response time of ~ 30 s. The selectivity coefficient of the sensor toward a number of different drugs with molecular similarities and some metal ions was evaluated. The electrode was examined for determination of LTG in real samples.