The Novel Gluconeogenesis Inhibitor FR225654 that Originates from Phoma sp. No. 00144 : I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties

FR225654, a novel gluconeogenesis inhibitor, was isolated from the culture broth of Phoma sp. No. 00144 and purified by adsorptive resin and reverse-phase column chromatography. This compound is a potent inhibitor of gluconeogenesis and is a promising candidate of anti-diabetic agent.