Cost - Minimization Analysis of Three Drugs Administered by Bladder Instillation for Prevention of Postoperative Recurrence of Bladder Cancer

OBJECTIVE:To evaluate the economic effects of 3 drugs administered by bladder instillation in the prevention for postoperative recurrence of bladder cancer.METHODS:A total of 126 patients with superficial bladder cancer after transurethral electroresection of bladder tumor(TURBT) were enrolled and randomly assigned to receive 30 mg THP,20 mg HCPT or 20 mg MMC dissolved in 40 mL sodium chloride by bladder instillation for 12 months.All patients were followed up for 3～24 months.The recurrence of bladder cancer was observed and the pharmacoeconomic analysis was conducted.RESULTS: The tumor recurrent rates in THP group,HCPT group and MMC group were 18.18%,21.43%and 20.00%,respectively (P 0.05),and the total medical costs were 15 924.36 yuan,12 018.36 yuan and 8 580.36 yuan,respectively.CONCLUSION: Group MMC is the preferable one among the three groups.