Analysis of Alternatively Spliced Domains in Multimodular Gene Products - The Extracellular Matrix Glycoprotein Tenascin C

In 1977 it was discovered that the one-gene-one-enzyme hypothesis was not true (Chow et al.,1977; Berget at al., 1977). The primary transcription product can be spliced in different ways and give rise to several proteins depending on the exons being present in the final mRNA. This phenomenon is called alternative splicing and indeed is common to many genes. Several possible modes of alternative splicing are known and the most common one is the inclusion or exclusion of an exon, the exon skipping.