Molecular determinants of outcome in sorafenib-treated patients with hepatocellular carcinoma
2013
Purpose
Preclinical studies show that sorafenib, a multitarget kinase inhibitor, displays anti-proliferative, anti-angiogenic, and pro-apoptotic properties in hepatocellular carcinoma (HCC). However, the determinants of sorafenib sensitivity in vivo remain largely unknown.
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