Synthesis, characterization and antimicrobial studies of novel N-substituted napthofuran carboxamides

Prompted by the varied biological activities of carboxamides and napthofurans, a series of Nsubstituted napthofuran carboxamides (4a-f) derived from napthofurans were prepared by treating aromatic primary amines with naphofuroic acids (3a-c) employing POCl3. The structures of these novel compounds were confirmed by elemental analysis and spectral data. All title compounds were screened for their antimicrobial activities. The screening data indicated that tested compounds were found to be less active than the standard drugs. A comparative study of antimicrobial activities of synthesized carboxamides is done.