On the Horizon From the ORS Using Mathematical Modeling to Design Effective Regenerative Medicine Strategies for Orthopaedics

The acceleration of scientific discovery in orthopaedic regenerative medicine and its transformation into bedside application require a paradigm shift in computational methods and strategies. Computational modeling must move from static simulations to adaptive methods that predict integrative physiology and physics from the molecular scale to human body scale. Computational methods have been extensively used tostudymusculoskeletalsystemsand go hand in hand with experimental studies. However, computational methods have primarily modeled a moment in time and not the adaptive response to altered environments produced by mechanical or biologic intervention. Computational strategies must be developed that integrate biologicremodelingrulesandpredict how musculoskeletal systems will respond over time. As we better understand musculoskeletal systems,