Observation on silver nanoparticle interference on serum C-reactive protein measurement -

Cheon K, Ozene N. Observation on silver nanoparticle interference on serum C-reactive protein measurement. Adv Lab Med Int. 2019; 8: 1 - 3. ABSTRACT The nanoparticle is a new substance that is widely used at present. The effect of nanoparticle interference on the laboratory investigation in clinical laboratory is an interesting issue. The interference of gold nanoparticle has just been reported on the viral load measurement. Here, the authors report the observation on the silver nanoparticle interference on serum C-reactive protein measurement. Clinically, C reactive protein (CRP) is a useful indicator for risk classification and monitoring of several diseases. The CRP is a basic common test in clinical laboratory. The authors performed an experimental study. Overall 30 blood samples are analyzed in the present study. Each blood sample is divided into two separated parts. The first part is used as naive group and the second part is added by 1 microliter of silver nanoparticle solution. All samples are analyzed for serum CRP level by the same immunoassay in the same clinical laboratory under the same standard quality control process. There is a significant difference of the CRP value in the group without (1.2 + 0.5 mg/L) and with (3.1 + 0.6 mg/L) nanoparticle. Hence, the nanoparticle solution can cause aberrant result of immunoassay test for CRP. Full text available at https://drive.google.com/file/d/1MKxjU2bNTf2YqxQIsJGal7f1xo-NtWEl/view