Cryoprecipitate for external use of anal fistula of postoperative wound repair affect clinical research

Objective To study the cryoprecipitate effect of local external treatment of anal fistula surgical wound repair. Methods A total of 95 cases of low simple anal fistula patients was chosen, and was divided into three groups according to random number table method. The cryoprecipitate group (n=32 cases) began with cryoprecipitate dressing (2 layer) even to fill in a wound, once per day. The Kangfuxin group (n=32 cases) used Kangfuxin solution. The exposed burn ointment (MEBO) group (n=31 cases) used MEBO to cover the wound. The healing time, postoperative wound healing rate, the granulation tissue growth, new epithelial coverage, and adverse reactions were observed. Results The cryoprecipitate group in 14 d and 21 d had postoperative wound healing rate (60.97±4.20)% and (97.69±1.79)%, wound healing time (21.31±2.08)days; it had higher healing rate and shorter healing times compared to other two groups (P<0.05). Wound repaired more neatly; and 14d and 21d after the operation, wound granulation tissue growth rate[(61.06±13.29)% and (97.63±2.81)%]and new epithelial coverage[(33.03±4.15)% and (94.97±4.36)%]were more than the control groups (P<0.05) with less adverse reactions relative to control groups. Conclusions The cryoprecipitate contained in the composition has a strong biological activity. It can promote the wound tissue cell growth, and promote the wound repair. Key words: Plasma; Precipitation; Rectal fistula/SU; Surgical wound infection/TH