Pharmacokinetics of mitomycin C after resection of peritoneal carcinomatosis and intraperitoneal chemohyperthermic perfusion.

Abstract Over the last few years surgery on patients with abdominal malignancies has become more aggressive but the majority of patients present locoregional recurrence as peritoneal dissemination. Cytoreductive surgery followed by intraperitoneal chemohyperthermic perfusion (ICHP) has been described for treatment and prevention of locoregional cancer spread from various origins. This paper reports our study of the pharmacokinetics of mitomycin C (MMC) administered by intraperitoneal chemohyperthermic perfusion (ICHP) in patients with peritoneal carcinomatosis. 28 patients received MMC 20 mg/m2 intraperitoneally as a perfusion over 60 min. MMC was determined in perfusate, plasma and urine samples with a UVHPLC method. A compartmental model was used to fit the drug concentrations in plasma and perfusate.Our results showed a mean maximum plasma concentration (Cmax) of 0.14±0.086 μg/ml with a peak time (Tmax) of 48..7 ± 5.61 min. The mean area under the curve (AUC) and terminal half-life (t1/2 ) were 15.8 ± ...