Corneal Topographic, Anatomic, and Biomechanical Properties in Severe Obstructive Sleep Apnea–Hypopnea Syndrome

PURPOSE: To determine corneal topographic, anatomic, and biomechanical properties in patients newly diagnosed with severe obstructive sleep apnea-hypopnea syndrome (OSAHS). METHODS: This is a cross-sectional study including 25 patients recently diagnosed with severe OSAHS (apnea-hypopnea index above 30) and a paired control group of 25 healthy subjects. All patients underwent a complete eye examination with an elevation topography Pentacam Scheimpflug study and a study with Reichert Ocular Response Analyzer, collecting several topographic, anatomic, and biomechanical variables. RESULTS: Fifty eyes of 25 patients (23 of them were men) diagnosed with OSAHS by somnography and the same number of healthy subjects (23 of them were men) were included, with an average age of 64 +/- 11 years (range 45-78 years) for cases and an average age of 64 +/- 11 years (range 45-81 years) for the controls. No differences were found in keratometry, cylinder, refractive indexes, Bad-D, or pachymetry. The mean corneal volume for cases was 58.64 +/- 3.05 mm and for the controls 60.48 +/- 3.33 mm (P = 0.005). The mean minimum radius for cases was 7.49 +/- 0.31 and for the controls 7.36 +/- 0.30 (P = 0.035). The mean elevation in apex for cases was 8.46 +/- 5.18 and for the controls 2.38 +/- 2.36 (P