Förster Resonance Energy Transfer-Based Dual-Modal Theranostic Nanoprobe for In Situ Visualization of Cancer Photothermal Therapy
2018
The visualization of the treatment process in situ could facilitate to accurately monitor cancer
photothermal therapy (PTT), and dramatically decrease the risk of thermal damage to normal cells and
tissues, which represents a major challenge for cancer precision therapy. Herein, we prepare
theranostic nanoprobes (NPs) for Forster resonance energy transfer (FRET)-based dual-modal
imaging-guided cancer PTT, and clear visualization of the therapeutic process. The FRET-based
theranostic NPs exhibit high FRET efficiency (88.2%), good colloidal stability, and tumor-targeting
ability. Tumor tissue and surrounding blood vessels are visualized clearly by FRET-based NIR
fluorescence imaging with a high signal-to-background ratio (14.5) and photoacoustic imaging with an
excellent resolution at 24 h post injection of NPs. Under the guidance of dual-modal imaging, the
NPs-induced photothermal effect selectively destructs cancer cells, simultaneously decreasing the FRET
efficiency and leading to fluorescence and photoacoustic signal changes. The sensitive self-feedback
process enables the in situ visualization of therapeutic process and precision guidance of in vivo cancer
PTT. A high therapeutic efficacy and minimum side effects are achieved in C6 tumor-bearing nude mice,
holding great promise for precision therapy and cancer theranostics.
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